Newt Limb Regeneration An The Effect Of Double Limb Amputation
Loading...
Authors
Tacke, Bill
Advisor
James Manion
Vincent Palese
Walter Jankowski
Vincent Palese
Walter Jankowski
Editor
Date of Issue
1972-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Newt Limb Regeneration An The Effect Of Double Limb Amputation
Other Titles
Type
thesis
Description
Abstract
The ability to regenerate is a fundamental property of living matter. In higher vertebrates, however the regenerative capacity is limited. Most are unable to regenerate appendages. This ability seems to have reached the amphibians, however, before being lost. Urodele amphibians are the most noted for limb regeneration, although anuran larvae also possess this capacity. The adult frog has lost the power to regenerate a limb normally, but through artificial induction, even these can be led to regenerate a limb-like structure (Singer, 1958). Xenopus laevis, a primitive frog (Rostand, 1932), also is capable of regenerating an amputated limb, although the new growth tends to be heteromorphic and occurs less readily after proximal amputation (Beetschen, 1952).
This paper is concerned with the phenomenon of limb regeneration in the urodele. The histological processes will be examined and reference will be made to phases of regeneration as outlined by Schotte and Butler (1942) and Singer (1952). Early in the days following limb amputation, cells accumulate to form a regenerate blastema at the tip of the limb stump (Singer, 1952). Research on the origin of these blastema cells points to a dedifferentiation of mesodermal tissues (Chalkley, 1954; Trampusch and Harrebomee, 1965). The importance of the formation of an apical cap from migrating epidermis has also been examined (Thornton, 1957).The ability to regenerate is a fundamental property of living matter. In higher vertebrates, however the regenerative capacity is limited. Most are unable to regenerate appendages. This ability seems to have reached the amphibians, however, before being lost. Urodele amphibians are the most noted for limb regeneration, although anuran larvae also possess this capacity. The adult frog has lost the power to regenerate a limb normally, but through artificial induction, even these can be led to regenerate a limb-like structure (Singer, 1958). Xenopus laevis, a primitive frog (Rostand, 1932), also is capable of regenerating an amputated limb, although the new growth tends to be heteromorphic and occurs less readily after proximal amputation (Beetschen, 1952).
This paper is concerned with the phenomenon of limb regeneration in the urodele. The histological processes will be examined and reference will be made to phases of regeneration as outlined by Schotte and Butler (1942) and Singer (1952). Early in the days following limb amputation, cells accumulate to form a regenerate blastema at the tip of the limb stump (Singer, 1952). Research on the origin of these blastema cells points to a dedifferentiation of mesodermal tissues (Chalkley, 1954; Trampusch and Harrebomee, 1965). The importance of the formation of an apical cap from migrating epidermis has also been examined (Thornton, 1957).
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences