Nursing burnout is a major problem faced by healthcare systems in the United States and all over the world. Ondriova (2017) reported, “the rate of prevalence of burnout in the profession of nursing is significant” (p. 18). Mannangi, Dupiton, Boutin and Angus (2018) define nursing burnout as, “high emotional exhaustion, depersonalization, and a sense of reduced personal accomplishment in professionals who provide direct care to others” (p. 4). The purpose of this evidence-based practice brief is to examine the effectiveness of burnout prevention strategies within the workplaces of registered nurses. For registered nurses (RN) between the ages of 20 and 65, are mindfulness-based burnout prevention strategies compared to incentive-based burnout prevention strategies more effective at reducing self-reported rates of burnout? By identifying and implementing nursing burnout prevention strategies within healthcare facilities, the rates of self-reported nursing burnout may be reduced. Implementing nursing burnout prevention strategies may improve nurse job satisfaction, indirectly increasing patient satisfaction. Job satisfaction will positively reflect on all phases of the nursing process [assessment, diagnosis, planning, intervention, evaluation] to improve the overall care given to patients.