The Theories Of The Inheritance Of The Iso-Agglutinogens In The Blood

Abstract

There has been of late a great deal of interest in and investigation of blood grouping from a genetic standpoint. It is the purpose of this paper to give and discuss the present status of the theories regarding the inheritance of these agglutinating factors. Dr. Karl Landstiner, a native of Austria, born in Vienna where he carried on the original research work in relation to blood grouping, but now an attache of the Rockerfeller Institute for Medial Research, was first to recognize serological differences in human blood. In 1901 he found that twenty-two individuals whose blood he had examined could be divided into three distinct groups or types. When the serum of one normal, healthy person and the red blood cells of another are mixed, instead of mixing freely the red blood cells often clump or glue together. This phenomenon of clumping or gluing together is termed iso-agglutination or agglutination. There has been of late a great deal of interest in and investigation of blood grouping from a genetic standpoint. It is the purpose of this paper to give and discuss the present status of the theories regarding the inheritance of these agglutinating factors. Dr. Karl Landstiner, a native of Austria, born in Vienna where he carried on the original research work in relation to blood grouping, but now an attache of the Rockerfeller Institute for Medial Research, was first to recognize serological differences in human blood. In 1901 he found that twenty-two individuals whose blood he had examined could be divided into three distinct groups or types. When the serum of one normal, healthy person and the red blood cells of another are mixed, instead of mixing freely the red blood cells often clump or glue together. This phenomenon of clumping or gluing together is termed iso-agglutination or agglutination. There has been of late a great deal of interest in and investigation of blood grouping from a genetic standpoint. It is the purpose of this paper to give and discuss the present status of the theories regarding the inheritance of these agglutinating factors. Dr. Karl Landstiner, a native of Austria, born in Vienna where he carried on the original research work in relation to blood grouping, but now an attache of the Rockerfeller Institute for Medial Research, was first to recognize serological differences in human blood. In 1901 he found that twenty-two individuals whose blood he had examined could be divided into three distinct groups or types. When the serum of one normal, healthy person and the red blood cells of another are mixed, instead of mixing freely the red blood cells often clump or glue together. This phenomenon of clumping or gluing together is termed iso-agglutination or agglutination.