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    A Study Of The Effects Of Hydrocortisone Acetate And Methotrexate Sodium On The Development And Progression Of Leukemia Induced By The Friend Leukemia Virus In Balb/C Mice

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    Author
    Conrad, Arthur; Harshman, John
    Advisor
    John Christenson; Rev. James Sullivan; Guido Bugni
    Date of Issue
    1974-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3271
    Title
    A Study Of The Effects Of Hydrocortisone Acetate And Methotrexate Sodium On The Development And Progression Of Leukemia Induced By The Friend Leukemia Virus In Balb/C Mice
    Type
    thesis
    Abstract
    The course of leukemia oroduceo by Friena leukemia virus (FLU) in male ano female BALB/c- mice was compared in hydrocortisone acetate-injected and methotrexate-injected mice. Statistic, hematologic, and pathologic studies showed that hydrocortisone acetate had a greater effect on slowing the leukemic growtn than did methotrexate sodium. Methotrexate had adverse effects on kidney morphology, whereas hydrocortisone caused no detectable disorders. Neither drug reversed the leukemic process. Application to the human problem of leukemia is discussed.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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