• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    4-Pentenoic Acid As An Inducer Of The Symptoms Of Reye's Syndrom In Laboratory Rats

    Thumbnail
    View/Open
    1977_HowardJ_THS_0001177.pdf (10.11Mb)
    Author
    Howard, Jane
    Advisor
    James Manion; Guido Bugni; John Christenson
    Date of Issue
    1977-04-01
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/3251
    Title
    4-Pentenoic Acid As An Inducer Of The Symptoms Of Reye's Syndrom In Laboratory Rats
    Type
    thesis
    Abstract
    The study includes a summary of clinical manifestations, biochemistry, and pathology of Reye's syndrome as well as potential etiologies and improved modes of treatment. It also explores a model introduced by Glasgow and Chase. Rats injected with A-pentenoic acid were tested for fatty degeneration of the liver, blood ammonia and glucose levels. Dosage size correlated with ammonia level and clinical observation several days following administration of the final dose suggests a completely reversible injury. A dose of 50 mg/kg injected 10 times every A hr best simulated the pattern of ammonia level in patients with Reye’s syndrome. The rats experienced fatty degeneration of the liver, hypoglycemia or normal levels of blood glucose. The study further compares the potential of this model to other methods of research.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV