The Effects On The Reproductive Organs Of Mice Following In Utero Exposure To Kepone

Abstract

Twelve pregnant Swiss-Webster mice were injected, intraperitoneally with Kepone on days 7-16 of gestation. Four mice received 0.1 ml of 2.5 mg of Kepone dissolved in 1.0 ml of sesame oil; four mice received 0.1 ml of 5.0 mg of Kepone dissolved in 1.0 ml of sesame oil; and the last four mice received only 0.1 ml of sesame oil. Litter size was reduced for those injected with Kepone. The male test progeny had a more rapid initial testicular development than the controls, but this slowed until at maturation, testicular development and histology were the same as the controls. The female test progeny had decreased corpus luteum formation, and a greater number and size of developing follicles than the controls; although both female test groups showed these abnormalities, only those receiving 5.0 mg of Kepone were significantly affected.