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    The Effects Of Indomethacin On The Biological Activities Of Bacterial LPS Treated Mice

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    1980_BateyW_THS_0001139.pdf (7.672Mb)
    Author
    Batey, William; Horton, Marc; LeClair, Katherine
    Advisor
    James Manion; Guido Bugni; Sister Alice Byrne
    Date of Issue
    1980-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3225
    Title
    The Effects Of Indomethacin On The Biological Activities Of Bacterial LPS Treated Mice
    Type
    thesis
    Abstract
    C3HeB/FeJ and RML Swiss-Webster mice were given various doses of indomethacin. Concentrations of 500 ug/mouse and greater proved to be toxic when injected 3 times a week. These strains of mice were pretreated with indomethacin and given 2 MLD50 doses of Salmonella Minnesota 1114 WT bacterial LPS. The indomethacin had no effect on the lethal effects of bacterial LPS. RML mice, pretreated with indomethacin, were given a primary and secondary injection of E.Coli 0113 bacterial LPS. The indomethacin had no effect on the ability of RML mice to elicit normal humoral antibody responses, although the indomethacin treated mice showed a higher secondary peak titer than the control mice; this was clinically significant.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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