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    A Screening Of Crude Organic Extracts For Mutagenicity Using Repair And Reversion Methods

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    1982_HarringtonB_THS_0001081.pdf (5.422Mb)
    Author
    Harrington, Brian
    Advisor
    James Manion; Arthur Westwell; Rev. Eugene Peoples
    Date of Issue
    1982-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3192
    Title
    A Screening Of Crude Organic Extracts For Mutagenicity Using Repair And Reversion Methods
    Type
    thesis
    Abstract
    A variety of samples isolated, from four types of sources (sponges, tunicates, algae, and cranberries) was tested for mutagenic effects. Established procedures used for mutagenic detection employed here consisted of a) genetic toxicology on Escherichia coli, b) Ames Spot Test, and c) the Ames Test. Of the twenty-two samples tested, seven showed some level of genetic toxicity on repair tests. Of these seven, three ( 1) a methyl hydroxide extract from the calcareous sponge, Leucetia microraphis, 2) an ethylacetate extract from the leaves of cranberries, and 3) an ether extract from Leucetia microraphis) showed significant or close to significant levels of mutagenicity in reversion studies.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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