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    Post Amputation Partial Blastema Formation In Adult Mice

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    1983_McCormackF_THS_0001044.pdf (3.386Mb)
    Author
    McCormack, Francis
    Advisor
    James Manion; Guido Bugni; Joseph Ward
    Date of Issue
    1983-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3172
    Title
    Post Amputation Partial Blastema Formation In Adult Mice
    Type
    thesis
    Abstract
    The formation of a partial blastema in adult mice was achieved through treatment of the amputation surface of toes with saturated solution of sodium chloride and a one mM equimolar solution of db-cAMP and theophylline. This study represents an improvement on the study first successful in stimulating partial blastema formation in mice (Neufeld, 1980) . The innovation employed in this study involved the use of db-cAMP and theophylline as an inhibitor of epidermal cell migration (epidermal migration onto the amputation plane inhibits regeneration). The advantages of chemical inhibition over surgical removal of epidermal tissue is discussed.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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