The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine

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Authors
Firpo, Meri
Advisor
James Manion
Rev. Joseph Harrington
Barry Ferst
Editor
Date of Issue
1984-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
The Cytotoxic And Kinetic Effects Of Asynchronous Cells Following The Administration Of Vincristine
Other Titles
Type
thesis
Description
Abstract
A growth curve was constructed for SCCVII-SF, a mouse squamous cell carcinoma cell line, in a culture of modified q-crle's medium. A toxicity curve was constructed for vincristine ,nd SCCVII-SF cells in the exponential phase of growth. Cells in mid-exponential phase were treated with a subtoxic level of vincristine for four hours. A count of mitotic cells was taken at intervals to determine whether vincristine caused a buildup of cells in mitosis after its removal. Results showed that cells continued to collect in mitosis for four hours after the removal of vincristine.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences