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    Preliminary Characterization Of The P3 Human Epithelial Cell Line For Radiobiological Reseach

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    1984_HollandJ_THS_0001018.pdf (2.387Mb)
    Author
    Holland, John
    Advisor
    Rev. Joseph Harrington; James Manion; Rev. Robert Butko
    Date of Issue
    1984-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3158
    Title
    Preliminary Characterization Of The P3 Human Epithelial Cell Line For Radiobiological Reseach
    Type
    thesis
    Abstract
    Preliminary experimentation was performed to characterize the P3 human epithelial cell line for radiobiological research. Specifically, work was done to determine if the cell line should be used to evaluate mechanisms of radiation damage and repair as revealed by survival response experimentation and via the 6-thioguanine mutation assay. Growth analysis was performed as well as a 6-thioguanine toxicity study and a 6-thioguanine mutation expression time curve. Preliminary results were obtained from survival experiments following P3 cell irradiation with 50 KvP X-rays, 6^co gamma rays, and Janus Reactor fission spectrum neutrons with a mean energy of 0.86 MeV. These and preliminary results of 6-thioguanine resistance mutation frequency experiments utilizing Janus Reactor fission spectrum neutrons will be discussed.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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