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    Hemoglobin Synthesis In Mice Doubly Heterozygous For Alpha And Beta Thalassemia

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    1984_SmithE_THS_0001004.pdf (2.154Mb)
    Author
    Smith, Eric
    Advisor
    John Christenson; James Manion; Rev. Robert McCarthy
    Date of Issue
    1984-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3149
    Title
    Hemoglobin Synthesis In Mice Doubly Heterozygous For Alpha And Beta Thalassemia
    Type
    thesis
    Abstract
    The extent of imbalance between the synthesis rate of «-globin polypeptide chains relative to B-globin chains in thalassemic mice is one of the major factors in determining the pathophysiology of thalassemia. Mice doubly heterozygous for both a mutant ®<-thalassemic chromosome and a /?-thalassemic chromosome exhibited a hypochromic, microcytic anemia with mild reticulocytosis and erythrocytosis. However, the erythrocytes of these mice displayed few signs of hemolysis, or poikilocytosis, and did not contain visible inclusion bodies. Analysis of the relative rates of globin chain syntheses in vitro by ^H-leucine incorporation revealed the
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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