A Serological Study Of The Humoral Antibody Response Of (B10 .Ax A. WySn) F1 Mice With Friend Virus-Induced Erythroleukemia To Sheep Erythrocyte Antigens

Loading...
Thumbnail Image
Authors
Coffing, Cyndra
Advisor
Fr. Joseph Harrington
Jean Smith
Philip Wittman
Editor
Date of Issue
1985-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
A Serological Study Of The Humoral Antibody Response Of (B10 .Ax A. WySn) F1 Mice With Friend Virus-Induced Erythroleukemia To Sheep Erythrocyte Antigens
Other Titles
Type
thesis
Description
Abstract
Friend virus (FV) is a murine leukemia virus. Previous studies have indicated that a profound humoral immunosuppression accompanies the erythroleukemia caused by FV. The presence of antibodies to Friend virus and sheep erythrocytes in the plasma of erythroleukemic mice which are capable of mounting an immune response to FV was tested using agglutination and cell binding assays in order to determine if humoral immunosuppression exists in the bloodstream. Friend virus-infected mice exhibited the same antibody response as normal mice, so no immunosuppression was discovered. The immunosuppressive effects of the disease are under genetic control. A better understanding of immunosuppression effects of this disease leads to a better understanding of leukemia and its genetic control.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences