Show simple item record

dc.contributor.advisorJames Manion
dc.contributor.advisorJean Smith
dc.contributor.advisorJohn Semmens
dc.contributor.authorMitchell, Bradley
dc.date.accessioned2020-04-30T10:02:43Z
dc.date.available2020-04-30T10:02:43Z
dc.date.issued1985-04-01
dc.identifier.urihttps://scholars.carroll.edu/handle/20.500.12647/3132
dc.description.abstractThis study evaluated the teratogenic potential of mathorexate on the central nervous system of CD-I mice at low concentrations during early gestation. Pregnant mice were given C.i mg <2.5 mg/kg) of methotrexate by intramuscular injections on day 5 of gestation while pregnant control mice received an injection of distilled water. Fetuses were excised by cesarian sectioning on days 7 through 20 of gestation and sectioned for histological examination. Other mice from each group were allowed to go to term and the offspring were examined externally at 7 and 14 days of age. An increased mortality rate, a decrease in fetal size, and slight internal hydrocephaly were ail observed in some of the mice which were prenatally exposed to the methotrexate.
dc.titleMethotrexate As A Teratogenic Substance On The Central Nervous System Of CD-1 Laboratory Mice
dc.typethesis
carrollscholars.object.degreeBachelor's
carrollscholars.object.departmentLife & Environmental Sciences
carrollscholars.object.disciplinesDevelopmental Biology
carrollscholars.legacy.itemurlhttps://scholars.carroll.edu/lifesci_theses/390
carrollscholars.legacy.contextkey12467462
carrollscholars.object.seasonSpring
dc.date.embargo12/31/1899 0:00


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record