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    Methotrexate As A Teratogenic Substance On The Central Nervous System Of CD-1 Laboratory Mice

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    1985_MitchellB_THS_000982.pdf (3.864Mb)
    Author
    Mitchell, Bradley
    Advisor
    James Manion; Jean Smith; John Semmens
    Date of Issue
    1985-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3132
    Title
    Methotrexate As A Teratogenic Substance On The Central Nervous System Of CD-1 Laboratory Mice
    Type
    thesis
    Abstract
    This study evaluated the teratogenic potential of mathorexate on the central nervous system of CD-I mice at low concentrations during early gestation. Pregnant mice were given C.i mg <2.5 mg/kg) of methotrexate by intramuscular injections on day 5 of gestation while pregnant control mice received an injection of distilled water. Fetuses were excised by cesarian sectioning on days 7 through 20 of gestation and sectioned for histological examination. Other mice from each group were allowed to go to term and the offspring were examined externally at 7 and 14 days of age. An increased mortality rate, a decrease in fetal size, and slight internal hydrocephaly were ail observed in some of the mice which were prenatally exposed to the methotrexate.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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