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    The Role Of Prostaglandin-H Synthase In Germ Cell Mutagenesis

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    1987_BerkramJ_THS_000940.pdf (2.821Mb)
    Author
    Berkram, Jennifer
    Advisor
    John Christenson; John Addis; Larry Waters
    Date of Issue
    1987-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3107
    Title
    The Role Of Prostaglandin-H Synthase In Germ Cell Mutagenesis
    Type
    thesis
    Abstract
    The role of prostaglandin-H synthase in the activation of dimethylnitrosamine to induce genetic mutations was studied. The test organisms used were two strains of Drosophila melanoaaster. A comparison was made to estimate the proportions of mutations resulting from dimethylnitrosamine-demethylase activation of dimethylnitrosamine and from prostaglandin-H synthase activation of the chemical. Sex-linked recessive lethal tests were performed and statistically evaluated to determine whether or not prostaglandin-H synthase could serve as an alternate or major pathway in metabolism of the chemical dimethylnitrosamine. The results of these tests indicate that prostaglandin-H synthase is probably not involved in the mutation process.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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