A Study Of The Aminoglycoside-Induced Mechanisms That Cause Auditory Toxicity In Guinea Pigs

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Authors
Truax, Allan
Advisor
John Christenson
Fr. Joseph Harrington
John Hart
Editor
Date of Issue
1987-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
A Study Of The Aminoglycoside-Induced Mechanisms That Cause Auditory Toxicity In Guinea Pigs
Other Titles
Type
thesis
Description
Abstract
Aminoglycosides have been associated with the preferential loss of hair cells; first in the basal portion of the organ of Corti and later in the apical portion of the organ of Corti. One current hypothesis is that a direct correlation exists between the concentration of aminoglycoside in the hair cells and destruction of the hair cells. The results of this experiment indicated that there were no detectable differences in drug concentrations between the basal portions and the apical portions of the organ of Corti. Interpretation of these results suggests that the preferential loss of hair cells is not due to differences in drug concentrations between the basal and apical hair cells.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences