A Study Of The Aminoglycoside-Induced Mechanisms That Cause Auditory Toxicity In Guinea Pigs

Abstract

Aminoglycosides have been associated with the preferential loss of hair cells; first in the basal portion of the organ of Corti and later in the apical portion of the organ of Corti. One current hypothesis is that a direct correlation exists between the concentration of aminoglycoside in the hair cells and destruction of the hair cells. The results of this experiment indicated that there were no detectable differences in drug concentrations between the basal portions and the apical portions of the organ of Corti. Interpretation of these results suggests that the preferential loss of hair cells is not due to differences in drug concentrations between the basal and apical hair cells.