Identification of Laminin Domains That Promote Tumor Cell Adhesion
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Authors
Freitag, Corby
Advisor
John Addis
Rev. Joseph Harrington
Tomas Graman
Rev. Joseph Harrington
Tomas Graman
Editor
Date of Issue
1991-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Identification of Laminin Domains That Promote Tumor Cell Adhesion
Other Titles
Type
thesis
Description
Abstract
The process of metastasis requires tumor cells to migrate through the basement membrane which consists of laminin, a glycoprotein which promotes the adhesion of HT-1080 fibrosarcoma cells. The present study was designed to test four peptides, corresponding to short sequences of the intact laminin molecule, for cell adhesion-promoting activity. By using three different cell migration assays, the four peptides were monitored for their cell adhesive-promoting activity. Results were obtained showing some cell adhesive-promoting activity from all four peptides.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences