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    Identification of Laminin Domains That Promote Tumor Cell Adhesion

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    1991_FreitagC_THS_000482.pdf (1.881Mb)
    Author
    Freitag, Corby
    Advisor
    John Addis; Rev. Joseph Harrington; Tomas Graman
    Date of Issue
    1991-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/3040
    Title
    Identification of Laminin Domains That Promote Tumor Cell Adhesion
    Type
    thesis
    Abstract
    The process of metastasis requires tumor cells to migrate through the basement membrane which consists of laminin, a glycoprotein which promotes the adhesion of HT-1080 fibrosarcoma cells. The present study was designed to test four peptides, corresponding to short sequences of the intact laminin molecule, for cell adhesion-promoting activity. By using three different cell migration assays, the four peptides were monitored for their cell adhesive-promoting activity. Results were obtained showing some cell adhesive-promoting activity from all four peptides.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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