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    Alleviation of the Negative Effects of Restraint Stress on Cognitive Learning and Retention in Rats by Estrogen and Estrogen + Progesterone

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    2003_HagerJ_THS_000828.pdf (24.40Mb)
    Author
    Hager, Jonathan
    Advisor
    Jacqueline Brehe; Marilyn Schendel; Gerald Shields
    Date of Issue
    2003-04-01
    Subject Keywords
    Cognitive learning; Estrogen; Hormones, Sex; Memory; Progesterone; Stress (Psychology)
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2976
    Title
    Alleviation of the Negative Effects of Restraint Stress on Cognitive Learning and Retention in Rats by Estrogen and Estrogen + Progesterone
    Type
    thesis
    Abstract
    Although the positive effects of female hormones on central nervous system function have been well documented, the actions of estrogen and progesterone on the known negative effect of stress on learning and retention have been examined in only a limited number of studies. This study used ovariectomized rats, injected with pharmacological dosages of estrogen or estrogen plus progesterone. The animals were placed in restraints to apply non-escapable stress and then were tested in a Morris water maze to evaluate cognitive learning and memory. Rats were injected, stressed and run through the maze until the maze was learned. The hypothesis was that estrogen and estrogen plus progesterone would help alleviate stress thereby increasing cognitive learning and retention. The stressed rats receiving estrogen + progesterone had a significantly increased retention compared to stressed rats. No statistically significant effects of female hormones on the alleviation of stress on learning were found.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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