• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Effects of Estradiol and Tamoxifen on Leukocyte Distribution in Response to Restraint Stress in Mice (Mus musculus)

    Thumbnail
    View/Open
    2004_DuchesneauJ_THS_000784.pdf (5.176Mb)
    Author
    Duchesneau, Julianna
    Advisor
    Jacqueline Brehe; Grant Hokit; Joan Stottlemyer
    Date of Issue
    2004-04-01
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2963
    Title
    Effects of Estradiol and Tamoxifen on Leukocyte Distribution in Response to Restraint Stress in Mice (Mus musculus)
    Type
    thesis
    Abstract
    Selective estrogen receptor modulators (SERMs), drugs that either mimic or block the action of estrogen but do not have its side effects, have been under intense research since the early 20th century because of their distinct biological functions as antagonists and agonists in cells through their unique molecular conformations. Previous, unpublished research has found a correlation between a reduction in the leukocytic stress response in mice and injection with a natural form of estrogen, estradiol. The present study tested the effects of a SERM, tamoxifen, on the leukocyte distribution in mice after subjection to restraint stress. No difference was found in the leukocyte distribution between stressed mice that were treated with tamoxifen and those that were injected with the vehicle. Further, in opposition to previous work, there was no difference found in the leukocyte distribution in mice injected with estradiol, which exhibited an augmented leukocytic stress response, compared to the mice that were injected with the vehicle.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV