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    Differential Expression of Mitochondrial Proteins in Alzheimer’s Disease Patients Compared to Age-Matched Controls

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    2004_FlahertyE_THS_000785.pdf (1.660Mb)
    Author
    Flaherty, Erin
    Advisor
    Marilyn Schendel; John Addis; Joan Stottlemyer
    Date of Issue
    2004-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2962
    Title
    Differential Expression of Mitochondrial Proteins in Alzheimer’s Disease Patients Compared to Age-Matched Controls
    Type
    thesis
    Abstract
    To date, the pathology of Alzheimer’s remains unknown, and many researchers have focused on the mitochondria as playing a significant role in its progression. In earlier studies, it was found that mRNA levels of mitochondrial proteins of Alzheimer’s Disease patients were altered in mouse and human models. Additional research is warranted to determine if the mRNA differences are translated to the protein level. It has been shown that mitochondrial genes are differentially expressed in Alzheimer’s patients when compared to age-matched controls. I propose the levels of the translated gene product will also be altered. To test this hypothesis a proteomic approach utilizing 2-D electrophoresis to separate mitochondrial proteins and compare expression between diseased and control samples was used. These results are preliminary and further trials will cement the results.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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