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    Effects of Estrous Stage on Leukocyte Distribution in Response to Restraint Stress in Mice (Mus musculus)

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    2004_SimonsM_THS_000812.pdf (3.762Mb)
    Author
    Simons, Marilee
    Advisor
    Jacqueline Brehe; Grant Hokit; Joan Stottlemyer
    Date of Issue
    2004-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2952
    Title
    Effects of Estrous Stage on Leukocyte Distribution in Response to Restraint Stress in Mice (Mus musculus)
    Type
    thesis
    Abstract
    Research has shown that there are interactions between the stress response and the immune system through the glucocorticoids. It has also been documented that estrogen and progesterone may have immunomodulatory effects and that the stress response may be modulated by the estrous cycle and the cyclic hormone levels associated with it. However, the connections between the stress response, the immune system, and the estrous cycle are not well understood. I examined changes in vaginal cytology and utilized simple leukocyte differential counts to determine if changes in the stress response correspond to the stages of the estrous cycle in Mus musculus. My results indicate that the stress treatment became significantly less effective throughout the experiment due to a habituation effect. Therefore, no definitive conclusions regarding the estrous cycle and the immune system could be made.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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