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    Identification of Key Binding Partners of Elongin C

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    2006_MaffitA_THS_000712.pdf (2.860Mb)
    Author
    Maffit, Allie
    Advisor
    Sam Alvey; Ron Wilde; Murphy Fox
    Date of Issue
    2006-04-01
    Subject Keywords
    Elongin C, prostate, cancer
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2929
    Title
    Identification of Key Binding Partners of Elongin C
    Type
    thesis
    Abstract
    Cancer is the second leading cause of death in the United States. Prostate cancer affects one in seven men in the United States. Thus, prostate cancer provides a very serious healthy threat to men in the United States. Unfortunately, not much is known as to how normal prostate cells are transformed into a cancerous state, or how once transformed remain in the cancerous state. A study preformed by Porkka et. al in 2002 revealed that Elongin C is over expressed in prostate cancer cell lines. I hypothesize that over expression of Elongin C could inappropriately stabilize or destabilize key proteins involved in cell regulation leading to the mutation and or proliferation of cancerous cells. Through the use of a two-hybrid screening process I have identified four proteins within the prostate cell that interact with Elongin C.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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