The Effect of Advanced Glycation End Product Inhibition on the Development of Diabetic Encephalopathy in Rats
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Authors
Gay, Nathanael
Advisor
Jacqueline Brehe
Anne Perkins
Ron Wilde
Anne Perkins
Ron Wilde
Editor
Date of Issue
2007-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
The Effect of Advanced Glycation End Product Inhibition on the Development of Diabetic Encephalopathy in Rats
Other Titles
Type
thesis
Description
Abstract
Advanced glycation end product (AGE) endogenous proliferation has been identified as a result of long term hyperglycemia associated with diabetes metillus. These products have been linked to various problems of aging and diabetes. This study used diabetic and non-diabetic rats. Each group received either the placebo, or the AGE inhibitor, aminoguanidine. The animals were then cognitively evaluated after eight weeks. I hypothesized that, diabetic rats receiving aminoguanidine would show reduced cognitive decline as compared with diabetic rats not receiving aminoguanidine. My observations support my hypothesis.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences