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    The Effect of Advanced Glycation End Product Inhibition on the Development of Diabetic Encephalopathy in Rats

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    2007_GayN_THS_000678.pdf (4.526Mb)
    Author
    Gay, Nathanael
    Advisor
    Jacqueline Brehe; Anne Perkins; Ron Wilde
    Date of Issue
    2007-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2915
    Title
    The Effect of Advanced Glycation End Product Inhibition on the Development of Diabetic Encephalopathy in Rats
    Type
    thesis
    Abstract
    Advanced glycation end product (AGE) endogenous proliferation has been identified as a result of long term hyperglycemia associated with diabetes metillus. These products have been linked to various problems of aging and diabetes. This study used diabetic and non-diabetic rats. Each group received either the placebo, or the AGE inhibitor, aminoguanidine. The animals were then cognitively evaluated after eight weeks. I hypothesized that, diabetic rats receiving aminoguanidine would show reduced cognitive decline as compared with diabetic rats not receiving aminoguanidine. My observations support my hypothesis.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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