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    Assignment By R-Banding Of X-Inactivation Status For A Patient With A Sex Chromosome Abnormality

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    1997_SandersE_THS_000316.pdf (2.302Mb)
    Author
    Sanders, Echo
    Advisor
    Marilyn Schendel; Grant Hokit; Mary Haag
    Date of Issue
    1997-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2889
    Title
    Assignment By R-Banding Of X-Inactivation Status For A Patient With A Sex Chromosome Abnormality
    Type
    thesis
    Abstract
    An R-banding protocol was developed in order to study the X-inactivation pattern of a patient with a duplicated X chromosome. R-banding was used because it results in the differential banding of the active and inactive X chromosome due to differing replication patterns with the active X being early replicating and the inactive X being late replicating. The results demonstrate that the patient’s normal X chromosome was early replicating as well as the duplicated region of the abnormal X chromosome. This suggests that the observed phenotype is a result of incomplete inactivation of the duplicated X chromosome.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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