Assignment By R-Banding Of X-Inactivation Status For A Patient With A Sex Chromosome Abnormality

Loading...
Thumbnail Image
Authors
Sanders, Echo
Advisor
Marilyn Schendel
Grant Hokit
Mary Haag
Editor
Date of Issue
1997-04-01
Subject Keywords
Publisher
Citation
Series/Report No.
item.page.identifier
Title
Assignment By R-Banding Of X-Inactivation Status For A Patient With A Sex Chromosome Abnormality
Other Titles
Type
thesis
Description
Abstract
An R-banding protocol was developed in order to study the X-inactivation pattern of a patient with a duplicated X chromosome. R-banding was used because it results in the differential banding of the active and inactive X chromosome due to differing replication patterns with the active X being early replicating and the inactive X being late replicating. The results demonstrate that the patient’s normal X chromosome was early replicating as well as the duplicated region of the abnormal X chromosome. This suggests that the observed phenotype is a result of incomplete inactivation of the duplicated X chromosome.
Sponsors
Degree Awarded
Bachelor's
Semester
Spring
Department
Life & Environmental Sciences