• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    In Vitro Comparison Of Clarithromycin, Clarithromycin plus 14-Hydroxy Clarithromycin, and Azithromycin Against Haemophilus influenzae

    Thumbnail
    View/Open
    1998_ArnoldA_THS_000312.pdf (2.697Mb)
    Author
    Arnold, Amy
    Advisor
    Joseph Harrington; John Addis; Joan Stottlemyer
    Date of Issue
    1998-04-01
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2888
    Title
    In Vitro Comparison Of Clarithromycin, Clarithromycin plus 14-Hydroxy Clarithromycin, and Azithromycin Against Haemophilus influenzae
    Type
    thesis
    Abstract
    The antibiotic activities of clarithromycin, clarithromycin plus 14-hydroxy clarithromycin and azithromycin against Haemophilus influenzae were compared. This comparison was performed because both clarithromycin and azithromycin have proven to be effective against infections due to H. influenzae. H. influenzae is partially responsible for the prevalence of community-acquired pneumonia (CAP) in the United States. Currently, many infectious and non-infectious conditions can mimic CAP, thereby hindering diagnoses of the causative agents and the administration of the most effective treatments. The initial treatment of CAP is crucial in reducing the mortality and morbidity due to CAP, yet the difficulties in diagnosis and administration of appropriate treatments prevent the initial treatment from being precise. Since H. influenzae is partially responsible for CAP, the use of an antibiotic that actively inhibits its growth would decrease the prevalence of CAP due to this bacteria. Minimum inhibitory tests, minimum bactericidal tests, and time kill assays were performed on five different strains of H. influenzae in order to determine if one antibiotic was more active over another. The results were not conclusive, but did show that all three antibiotics were bactericidal towards H. influenzae. Further studies will need to be performed to determine if one antibiotic over another or a combination of antibiotics should be initially administered to CAP patients in which H. influenzae is the responsible pathogen.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV