• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Family with Bannayan-Riley-Ruvalcaba Syndrome: Linkage...

    Thumbnail
    View/Open
    1998_JelinekJ_THS_000298.pdf (3.459Mb)
    Author
    Jelinek, J. Adam
    Advisor
    Marilyn Schendel; Linda Beischel; John Christenson
    Date of Issue
    1998-04-01
    Subject Keywords
    Bannayan-Riley-Ruvalcaba syndrome, genetics
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2882
    Title
    Family with Bannayan-Riley-Ruvalcaba Syndrome: Linkage...
    Type
    thesis
    Abstract
    The purpose of this study was to locate the gene responsible for Bannayan-Riley-Ruvalcaba syndrome in an affected family. DNA was isolated from 13 members of the family and linkage studies were conducted. Twelve markers encompassing a specific region on chromosome 10 (10q23) were used in linkage analysis. DNA segments specific for each primer set were amplified using PCR (polymerase chain reaction) techniques and then analysis of the products was conducted using the ABI genetic analyzer. Alleles were then assigned to each family member and linkage was tested (LINKAGE 5.0). A maximum LOD score of 0.98 was obtained at marker D10S573. This gave an indication of linkage in the family but no definitive conformation was possible. Crossover events in the family were also examined in an attempt to localize the gene responsible for Bannayan-Riley-Ruvalcaba syndrome. All segments on chromosome 10 were ruled out for the BRR gene except the region between markers D10S215 and D10S2470.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV