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    Partial Isolation and Chemical Characterization of Cytotoxic Compounds in Freshwater Sponges

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    2008_BertoniA_THS_000631.pdf (2.171Mb)
    Author
    Bertoni, Aaron
    Advisor
    John Addis; Sam Alvey; Kyle Strode
    Date of Issue
    2008-04-01
    Subject Keywords
    Eunapius fragilis, Ephydatia muelleri, marine sponges
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2880
    Title
    Partial Isolation and Chemical Characterization of Cytotoxic Compounds in Freshwater Sponges
    Type
    thesis
    Abstract
    Marine sponges are known to produce or sequester compounds useful for defense against predation and to prevent fouling by parasites. Many of the compounds extracted from marine sponges have been shown to possess useful antitumoral properties. The present study investigates two species of freshwater sponges, Eunapius fragilis and Ephydatia muelleri, for possible cytotoxic compounds as determined by brine shrimp microassay. Results show that both species have cytotoxic compounds extractable in methanol and at least two cytotoxic compounds may be present in Eunapiusfragilis, both of which are extractable in hexane. The present study provides strong support for continued natural product research on freshwater sponges.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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