• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Neurological Effects of Chlorpyrifos on Prenatally-Exposed Rats

    Thumbnail
    View/Open
    2008_DenningK_THS_000637.pdf (3.664Mb)
    Author
    Denning, Kyle
    Advisor
    Jacqueline Brehe; Jennifer Glowienka; Murphy Fox
    Date of Issue
    2008-04-01
    Subject Keywords
    autism, chlorpyrifos
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2879
    Title
    Neurological Effects of Chlorpyrifos on Prenatally-Exposed Rats
    Type
    thesis
    Abstract
    Though extensively documented, autism is still poorly understood. Possible factors include prenatal or neonatal chemical exposure that causes declined synaptic transmission. One chemical, the pesticide known as chlorpyrifos, has been shown to cause anatomical differences in the areas of rats’ brains that are linked to behavioral symptoms closely related to autism. With the knowledge of the increased susceptibility ofmales to prenatal drug exposure, it was hypothesized that male rats exposed to chlorpyrifos before birth would exhibit such symptoms. Two tests, an elevated plus maze and a Morris water maze, were used to test anxiety and cognition, respectively. Anxiety tests yielded no differences between rats prenatally exposed to the chemical, or between males and females. Similarly, cognition tests showed no such correlations. Though these results suggest no apparent connection between chlorpyrifos and autism-like behavior, it is still unclear whether the rats experienced internal anatomical change due to their exposure. Used as a pilot study, this experiment could be coupled with a cellular analysis to fully illustrate the effects of chlorpyrifos.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV