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    Studies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types

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    1999_KnoxA_THS_000255.pdf (2.805Mb)
    Author
    Knox, Aaron
    Advisor
    Marilyn Schendel; Mary Haag; John Addis
    Date of Issue
    1999-04-01
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2842
    Title
    Studies of Mosaicism for Chromosomal Aneuploidy in Fetal Loss Using Fluorescence In Situ Hybridization on Several Tissue Types
    Type
    thesis
    Abstract
    The main objective ofthis study was to determine the presence and level of mosaicism for chromosomal aneuploidy in several cases of fetal demise that had previous indications of chromosome aberrations. The presence of aneuploidy was determined using fluorescence in situ hybridization (FISH) probes. Techniques that were utilized in attempts to prepare several tissue types for FISH are described. The analyses made with FISH provided useful data on the chromosomal makeup oftwo of the cases studied. In one case FISH results showed that the product of conception (POC) did not contain the trisomy 18 that is present at low levels in the mother’s blood cells. In the other case the miscarried fetus was previously identified as being mosaic for trisomy X. In this research project the presence ofvarying levels of trisomy X in both embryonic and placental tissue was confirmed
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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