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    Applications of Comparative Genomic Hybridization in a Clinical Cytogenetics Laboratory

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    2000_PhillipsL_THS_000215.pdf (2.494Mb)
    Author
    Phillips, Leslie
    Advisor
    Marilyn Schendel; Mary Haag; Joan Stottlemyer
    Date of Issue
    2000-04-01
    Subject Keywords
    Comparative genomic hybridization, chromosomal
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2824
    Title
    Applications of Comparative Genomic Hybridization in a Clinical Cytogenetics Laboratory
    Type
    thesis
    Abstract
    Comparative Genomic Hybridization (CGH) provides a method to rapidly detect amplifications and deletions of chromosomal material as small as 10 Mbp (Bentz et al. 1998) in an entire genome. Thus, this modem molecular cytogenetic technique was investigated in order to optimize a working protocol. DNA from a test sample and a reference sample was isolated, fluorescently labeled, and hybridized to normal male metaphase spreads. The spreads were then viewed using a fluorescent microscope and imaged using Perceptive Scientific Instruments’ (PSI) MacProbe fluorescence imaging program. Predicted results were found in some cases, but not in others, indicating that further testing is needed before CGH can be reliably used for clinical testing ofpatients.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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