• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Isosorbide and Chytridiomycosis in Panamanian Golden Frogs

    Thumbnail
    View/Open
    RolandoOFinal_2012.pdf (2.084Mb)
    Author
    Rolando, Olivia
    Date of Issue
    2012-04-01
    Subject Keywords
    chytridiomycosis, Batrachocytrium dendrobatidis, Atelopus zeteki, Panamanian Golden Frogs
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2799
    Title
    Isosorbide and Chytridiomycosis in Panamanian Golden Frogs
    Type
    thesis
    Abstract
    Global amphibian decline is an established problem, first noted over 40 years ago. Without an obvious cause beyond the natural factors, such as habitat loss, disease has risen as a reasonable explanation. Chytridiomycosis is an infectious disease targeting amphibians, namely frogs, in Central and South America. The fungus, Batrachochytrium dendrobatidis, has been shown to be inhibited by natural mixes of antimicrobial peptides (AMPs) found on the backs of susceptible and resistant frogs. A unique case, Atelopus zeteki, does not show the same use of AMPs. Rather, a heterocyclic diol, isosorbide, seems to be involved in their immunological response to B. dendrobatidis infection. Using liquid chromatography mass spectrometry, gas chromatography mass spectrometry, flame ionization detection, and chytrid bioassays, isosorbide was determined and suggested to function in an antimicrobial manner in A. zeteki. The lowest concentration exhibiting antimicrobial properties was 250 mM isosorbide against chytrid zoospores. The case study of A. zeteki is illustrative of how future infectious diseases’ activity could be quenched before such drastic losses occur. Additional research is needed to identify the antimicrobial properties of isosorbide in a quantitative manner and for determining whether the frog or the topical bacteria on the frog are synthesizing this compound.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV