• Login
    View Item 
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    •   Carroll Scholars Home
    • Life and Environmental Sciences
    • Life and Environmental Sciences Undergraduate Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Exploring the Role of Olfm1 in the Trafficking of GluR2- containing AMPA Receptors

    Thumbnail
    View/Open
    KramerS_2014_Final.pdf (889.6Kb)
    Author
    Kramer, Shelby
    Advisor
    Stefanie Otto-Hitt; Daniel Gretch; Kevin Stewart
    Date of Issue
    2014-04-01
    Metadata
    Show full item record
    URI
    https://scholars.carroll.edu/handle/20.500.12647/2774
    Title
    Exploring the Role of Olfm1 in the Trafficking of GluR2- containing AMPA Receptors
    Type
    thesis
    Abstract
    The interactions between post-synaptic receptors and pre-synaptic molecules are responsible for coordinating numerous human activities such as thought, behavior, memory, learning and homeostasis. Important excitatory post-synaptic receptors that alter strength of connections between pre- and post-synaptic neurons are ?-Amino-3-hydroxy- 5-Methylisoxazole-4-Propanoic Acid (AMPA) receptors (AMPARs). Understanding the molecular mechanisms that govern AMPAR trafficking to synapses and effects on synaptic plasticity are critical to understanding disease and normal neurological processes. The purpose of this research was to identify GluR2-interacting proteins that play important roles in AMPAR trafficking and to characterize the functional significance of AMPARs. The transmembrane protein Olfactomedin 1 (Olfm1) isoform 1, also called Noelin 1, was studied to determine the role that it plays in AMPAR trafficking at synapses. Unfortunately, cloning complications prevented a definitive conclusion on the nature of Olfm1’s role in AMPAR trafficking.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
    Collections
    • Life and Environmental Sciences Undergraduate Theses

    Browse

    All of Carroll ScholarsCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2023  DuraSpace
    DSpace Express is a service operated by 
    Atmire NV