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    Investigating the Role of PrP and Amyloid Beta Proteins in AD and Other Protein-Misfolding Diseases

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    CornishS_2015_Final.pdf (410.9Kb)
    Author
    Cornish, Steven
    Date of Issue
    2015-04-01
    Subject Keywords
    Prion, Alzheimer's
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2761
    Title
    Investigating the Role of PrP and Amyloid Beta Proteins in AD and Other Protein-Misfolding Diseases
    Type
    thesis
    Abstract
    Prion diseases are very rare, neurodegenerative diseases caused by misfolding of the Prion protein. The pathologies created by the misfolded protein are remarkably similar to those of Alzheimer’s disease. This paper provides a comprehensive study of the genomic and proteomic similarities between Prion proteins and several proteins implicated in Alzheimer’s disease (AD). While genomic similarity has been proven, studies are unclear as to whether any genomic mutations in PRNP affect the progression of AD. Studies have definitively proven that Prion protein interacts on a molecular level with several proteins implicated in AD. These interactions require further study to definitively prove whether they speed or slow AD progression, but current evidence indicates that Prion protein interaction will lead to faster progression of AD in vitro.
    Degree Awarded
    Bachelor's
    Semester
    Spring
    Department
    Life & Environmental Sciences
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    • Life and Environmental Sciences Undergraduate Theses

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