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    Global metabolic profiling of human joint fluid following a second ACL tear: A case report

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    StarkeJ_2019_Final.pdf (892.0Kb)
    Author
    Starke, Jenna
    Advisor
    Alyssa Hahn; Brandon Sheafor; Kelly Parsley
    Date of Issue
    2019-01-01
    Subject Keywords
    ACL tear, metabolic profiling
    Metadata
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    URI
    https://scholars.carroll.edu/handle/20.500.12647/2488
    Title
    Global metabolic profiling of human joint fluid following a second ACL tear: A case report
    Type
    thesis
    Abstract
    Objectives: The objective of this study was to investigate the acute metabolic response to injury using global, or untargeted, metabolic profiling. The purpose was to better understand the acute response to injury following a second traumatic joint injury. Methods: This study is a case report of a patient who had sustained two separate ACL tears in the same knee years apart. We extracted metabolites from healthy synovial fluid and human joint fluid following the patient’s second ACL tear and analyzed the metabolite extracts using liquid chromatography-mass spectrometry (LC-MS)-based global metabolic profiling. Results: We identified 1241 unique metabolite features in injured SF compared to healthy SF (Student’s t-test: FDR-adjusted p-value
    Degree Awarded
    Bachelor's
    Semester
    Winter
    Department
    Health Sciences
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    • Health Sciences Undergraduate Theses

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