Synthesis of CifiDABCO and mannose co-functionalized G(4)-PAMAM dendrimer for use in antibiotics
Synthesis of C16DABCO and mannose co-functionalized G(4)-PAMAM dendrimer is expected to yield a useful antimicrobial that is effective in binding to mannose specific lectins on bacterial fimbriae. Thus far, mannose has been attached to the dendrimer with near complete functionalization. C16DABCO and mannose cofunctionalized G(4)-PAMAM dendrimer have been synthesized, but not in sufficient quantities to allow examination of its the antibacterial properties. Future work includes optimizing the final synthesis and performing toxicity studies.