Epilepsy, a seizure disorder, is characterized by a disruption of electrical activity in the brain. Most commonly, epilepsy is diagnosed after a person has two or more seizures (Shafer, 2013). Worldwide 65 million people have epilepsy, 3.4 million of which are in the United States; 150,000 people are added to that number every year (Shafer, 2013). “One-third … of people with epilepsy … live with uncontrollable seizures because no available treatment works for them” (Shafer, 2013). Seizure Alert dogs (SADs) are certified service animals under the federal law that detect when a person is going to have a seizure and notify them before the seizure occurs (Epilepsy Foundation, 2007). The seizure alert dogs can also be trained to assist during and after the seizure by staying “close to their companions for the duration of the seizure, as well as fetch medications, a telephone or caretaker” (Epilepsy Foundation, 2007). The purpose of this Evidence-Based Practice review is to determine the effectiveness of seizure alert dogs (SAD) in reducing the frequency of seizures in those diagnosed with epilepsy. Healthcare providers can educate patients about alternatives to medical seizure therapy and can advocate for patients to own a SAD to improve patient outcomes and quality of life for patients with epilepsy.