Solid organ transplants (SOT) are often the only life saving or quality of life (QOL)-improvement measures that can be taken for patients with end-stage diseases. According to the National Council for Biotechnology Information (NCBI), a solid organ transplant is defined as “a treatment, not a cure, for end-stage organ failure of the kidney, liver, pancreas, heart, and lung” (2018). The World Health Organization (WHO) defines QOL as "an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns” (2022). The purpose of this evidence-based practice review is to examine the relationship between SOT and QOL in transplant patients. Nurses or other healthcare providers can use this information to provide more competent and holistic care for this vulnerable patient population.