It is safe to say not all women will experience depression as a side effect of contraception, but what if there was a way to tell if the form of birth control the woman chose could impact this behavior? Approximately 65% of women in the United States are currently on some form of birth control (CDC, 2019). There are different kinds of contraceptive methods including hormonal and non-hormonal used by sexually active women. With all of these options there are a plethora of side effects that may accompany them. Some expected side effects from hormonal contraceptives include cramps, acne, and mood changes. These mood changes could ultimately lead to chronic depression and negative self concept. In the United States, 1 in 10 women suffer from depression (CDC, 2020). The purpose of this evidence based practice review is to further explore the correlation between hormonal and non hormonal contraceptive methods with depression rates. Constant research is essential to keep up with best practices for women’s mental health. By looking into further research studies regarding contraceptive use, the decision-making process may be greatly altered in future women looking at contraception choices. As nurses, educating patients is essential to prevent future complications from arising. By knowing the correlation between depression development and contraceptive methods, nurses and other healthcare providers can better counsel patients to choose the best and most effective method for each individual.