Effects of Vitamin D3 Analogs on Human Breast Cancer Cells: A Systematic Review
Objective: To review published literature regarding the effect of vitamin D3 treatment on the rates of cell death and growth inhibition in cultured human breast cancer cells.
Methods: Literature identified using PubMed and CINAHL was evaluated for the impacts of treating breast cancer cells with vitamin D3 analogs.
Results: The majority of the literature supported vitamin D3 as a viable treatment option for breast cancer cells. Lab studies have shown anti-proliferative and apoptotic results among cells. This treatment is most effective when used in conjunction with other treatment options.
Conclusions: In lab settings, vitamin D3 analogs have shown promising effects on human breast cancer cells in terms of limiting growth and replication and inducing apoptosis. This systematic review concludes that vitamin D3 treatment can treat breast cancer. Future research should be conducted on humans with breast cancer.
Keywords: Breast Cancer Cells; vitamin D3; calcitriol; cancer treatment; growth inhibition; cell apoptosis.