Health Sciences Undergraduate Theses

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    Metabolomic Profiles of Articular Cartilage Vary By Osteoarthritis Grade
    (2020) Welhaven, Hope; Hahn, Alyssa; Gretch, Daniel; Parsley, Kelly
    Osteoarthritis (OA) is the most common chronic joint disease, characterized by the breakdown of the articular cartilage (AC). However, there are currently no therapeutic drug targets to slow the progression of disease because disease pathogenesis is largely unknown. Thus, the goals of this study were to (1) spatially map metabolism across regions of OA cartilage and (2) identify any metabolic differences in OA articular cartilage between grades III and IV in hopes of revealing potential drug targets. To accomplish this, AC from femoral heads were removed, homogenized, and metabolites were extracted for mass spectrometry analysis to generate metabolomic profiles of defined grades of OA. The results revealed that distinct metabolic phenotypes exist between articular cartilage from grades III and IV OA hip joints, but not across different regions of the diseased joint. The pathways that contributed the most to these differences between grades were associated with ascorbate metabolism, amino acid metabolism, fatty acid metabolism and vitamin metabolism (H, C, E, B5). These results suggest that radiography-confirmed grades III and IV OA are associated with distinct global metabolic phenotypes. The results of this study enhance our understanding of altered cartilage metabolism in OA which may lead to potential drug targets to slow, halt, or reverse cartilage damage in late stages of OA.
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    Global metabolic profiling of human joint fluid following a second ACL tear: A case report
    (2019-01-01) Starke, Jenna; Alyssa Hahn; Brandon Sheafor; Kelly Parsley
    Objectives: The objective of this study was to investigate the acute metabolic response to injury using global, or untargeted, metabolic profiling. The purpose was to better understand the acute response to injury following a second traumatic joint injury. Methods: This study is a case report of a patient who had sustained two separate ACL tears in the same knee years apart. We extracted metabolites from healthy synovial fluid and human joint fluid following the patient’s second ACL tear and analyzed the metabolite extracts using liquid chromatography-mass spectrometry (LC-MS)-based global metabolic profiling. Results: We identified 1241 unique metabolite features in injured SF compared to healthy SF (Student’s t-test: FDR-adjusted p-value
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    Use Of Medical Statistics To Improve Patient Care
    (1974-04-01) May, Bernadette; Sister Anne Bouffard; Nancy Campbell; Alfred Murray
    Veritably any text on organization and administration, information management, or hospital affairs will contain a chapter on statistics. And an almost universal reaction to "statistics," whether in a hospital, large corporation, or small private enterprise, is negative because "statistics lie"; they are regarded as cumbersome, unreliable, and difficult to read by many people. But the areas of compilation, utilization, and demonstration of statistical data can be challenging and interesting. By anyone's professional standards, statistics are certainly necessary. They contribute to effective management and control for an individual department and a total organization like no other form of information can. Businesses process large amounts of data, and a hospital is no exception. In general, data must be interpreted to be useful. Statistical information amounts to a concise, meaningful interpretation, assuming that the data is based upon uniform definitions among those collecting the data, and that the party coordinating the information has an understanding of where the data originates, where the statistics are needed, and what purpose they will ultimately serve. The statistical norms reflect current practice in the participating hospitals. Their validity is not assumed, but must be established in each instance, meaning that numbers illustrating a certain point must be compared with the data from which they are derived. If a certain figure demonstrates inadequate patient care, the patient's medical record must be examined. There must be a causal connection between the failure to meet the requirements and the injury caused to a person. If that connection can be made, then liability will and should follow. If the causal connection cannot be established there can be no negligence under these circumstances. Moreover, the procedure ensures that the norms will automatically reflect the. 3 changes in practice that occur with the passage of time.
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    Moral Law And Physician-Assisted Suicide
    (1995-04-01) Rupert, Jessie; Valerie Gager; Lee Harrison; Robert Walsh
    Each person is unique with an individual look, identity, perspective, and personality. Each will experience an individual death, different from all others. Although there are as many ways to experience the process of death as there are people, the scope of this paper will focus on the deaths of mentally competent patients who are near the end of a terminal illness. In this thesis, it will be demonstrated that society’s interpretation of moral laws must be modified with time and the acquisition of knowledge, and that the participation of physicians and patients in physician- assisted suicide must now be considered reasonable, justifiable, and ethical in exceptional cases. This paper will be presented in two main parts. First, the thesis will be analyzed and explained. There will be a brief discussion of what moral laws are, and reasons will be presented to show why our interpretation of them must change with time and the acquisition of knowledge. It will then be demonstrated why physician- assisted suicide has surfaced as such an important issue and why it must be discussed now. Some of the criteria used to help define exceptional cases and to know when the option of assisted suicide should be considered will be addressed. The final segment of the analysis and explanation will illustrate why physician-assisted suicide should be considered reasonable, justifiable, and ethical in exceptional cases. Second, after the thesis has been analyzed and explained, some of the most common objections to the arguments for physician-assisted suicide in exceptional cases will be addressed and responded to. The entire paper then will be reviewed briefly and summarized in the conclusion.
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    Living with an Individual with Duchenne Muscular Dystrophy: A Phenomenological Study
    (2011-04-01) Sternhagen, Jacob; Joni Walton; Jennifer Elison; Michelle Lewis
    Using Colaizzi’s Method of data analysis, which is a phenomenological approach, this paper explored the role that a primary caregiver plays in the daily life of an individual with Duchenne Muscular Dystrophy (DMD). DMD is a fatal inherited disease that typically appears in male children before the age of six with the child usually losing the ability to walk by age twelve (CDC, 2009). There is no known cure for this disease and treatment goals focus on minimizing symptoms and maximizing the individual’s quality of life. The data for the research was obtained from peer reviewed research which focused on DMD and two private interviews with the primary caregiver of the individual with DMD. The themes that arose from the data included the primary caregiver’s desire to seek out proactive healthcare providers, advocate for better treatment, eliminate or reduce environmental obstacles, and maintain normalcy in her child’s life. Conclusions that were formed from the research were the importance of healthcare professionals and school officials understanding the unique needs of the family. Additionally, including the individual with DMD is important so that he doesn’t experience alienation and exclusion from his peers. These are essential goals for community professionals and healthcare workers so that patients with DMD and their families can experience the highest quality of life.