Browsing by Author "Welhaven, Hope"

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Characterization of Urinary Metabolic Biomarkers of Autosomal Dominant Polycystic Kidney Disease (ADPKD): A Pilot Study

Bergstrom, Annika; Glimm, Matthew; Houske, Eden; Welhaven, Hope; June, Ronald; Hahn, Alyssa (2022)

Autosomal dominant polycystic kidney disease (ADPKD) is the most common heritable kidney disease. ADPKD results from a mutation in the genes (PKD1, PKD2) for the mechanosensitive proteins polycystin-1 (PC1) or polycystin-2 ...
Metabolomic Profiles of Articular Cartilage Vary By Osteoarthritis Grade

Welhaven, Hope (2020)

Osteoarthritis (OA) is the most common chronic joint disease, characterized by the breakdown of the articular cartilage (AC). However, there are currently no therapeutic drug targets to slow the progression of disease ...
Why NASA should care about osteoarthritis: Metabolomic Analyses to Provide Insight into the Risk of Joint Unloading in Microgravity Environments

Welhaven, Hope (2020-04-24)

A recurring issue NASA faces is the health of their space crews’ before, during, and after space missions due to microgravity. A lack of joint loading is known to reduce articular cartilage (AC) thickness and increase the ...